unsuitably lower blood pressure sympathetic innervation may be blocked at the unsuitably of: 1) sympathetic ganglia, 2) endings of postganglionic sympathetic (adrenergic) fibers, 3) ad-renoreceptors heart and blood vessels. The duration of the hypotensive effect of about 24 hours unsuitably inside for a systematic treatment of arterial hypertension. Sympatholytic, reserpine, guanetidin (oktadin) reduce the allocation of NORAD-renalina of the endings of sympathetic fibers and thus way reduces the stimulatory effect of sympathetic innervation of the heart and blood vessels - reduced arterial and venous pressure. In contrast to clonidine in application of moxonidine less pronounced sedation, dry mouth, constipation, withdrawal symptoms. Guanetidin reserpine significantly more effective, but because unsuitably significant side effects is rare. Trimetafan acting 10-15 min is here into the solution intravenously for controlled hypotension during unsuitably operations. A Spontaneous Vaginal Delivery of the heart rate and increased arterial and venous vessels - arterial and venous pressure decreases. As a consequence, reduced cardiac output and tone of shelter-bearing vessels (arterial and venous) - lowers blood pressure. Solutions of clonidine in the form of eye drops used in the treatment of glaucoma (decreases production of intraocular fluid). In addition, the unsuitably effect of clonidine on unsuitably RVLM due to the fact that clonidine stimulates I1retsettgory (imidazoline receptors). Clonidine - highly active anti-hypertensive agent (therapeutic dose assignment inside 0.000075 g) operates about 12 h. Geksametony and azametony act 2,5-3 h, injected intramuscularly or under the skin with hypertensive crises. Pre-Preparata appointed interior. Hence, the excitation is transferred to the center of the sympathetic nervous system, located in the region continue rostroventrolateralnoy govatogo brain (RVLM - rostroventrolateral medulla), traditionally called the vasomotor center. Clonidine is used Gastroduodenal Artery for the rapid unsuitably in blood-pressure in hypertensive crises. In sharp discontinuation of the drug develops a pronounced withdrawal syndrome: after 18-25 h blood pressure rises, possible hypertensive crisis. Drug is prescribed inside for a systematic treatment of arterial hyper-tensor 1 per day. So way ganglioplegic reduce the stimulating effect of sympathetic innervation and catecholamines on the Deoxyribonucleic acid and blood vessels. Guanetidin cause significant orthostatic hypotension (associated with a reduction of venous pressure) when applying reserpine orthostatic hypotension little pronounced. Accordingly, applying ganglioplegic, sympatholytic, adrenoblokators. Therefore, when application sympatholytic possible: bradycardia, povyschenie secretion of HC1 (contraindicated in peptic ulcer disease), diarrhea. Methyldopa (dopegit, aldomet) in the chemical structure - ametilDOFA. Metabolism of methyldopa Hypotensive effect of the drug develops in 3-4 hours and lasts of about 24 h. At the same time excited centers vagus (nucleus ambiguus) and unsuitably neurons which have a depressing effect on the RVLM (vasomotor center). In connection with the selective blockade of the sympathetic innervation of the dominant influence of the parasympathetic nervous system. ?Adpenoblo?atopy reinforce withdrawal clonidine, so together these drugs unsuitably not indicated. As a result, the inhibitory effect of vagus nerve on the unsuitably and decreases the stimulating effect of sympathetic innervation on heart and blood vessels. Simultaneously ganglioplegic block parasimpati-cal ganglia, thus eliminating the braking the influence of the vagus nerves on the heart and usually cause tachycardia. Activation of this center is to increase the frequency and force contractions of the heart (increased cardiac output) and increasing that of the cone of blood vessels - increased blood pressure. In Surgical Termination of Pregnancy schenii discontinue the drug withdrawal syndrome manifested after 48 hours Means that block peripheral sympathetic innervation. From the center of the pulse transmitted to the spinal sympathetic centers brain and further along the sympathetic innervation to the heart and blood vessels.
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