unsuitably lower blood pressure sympathetic innervation may be blocked at  the unsuitably of: 1) sympathetic ganglia, 2) endings of postganglionic  sympathetic (adrenergic) fibers, 3) ad-renoreceptors heart and blood vessels.  The duration of the hypotensive effect of about 24 hours unsuitably inside for a  systematic treatment of arterial hypertension. Sympatholytic, reserpine,  guanetidin (oktadin) reduce the allocation of NORAD-renalina of the endings of  sympathetic fibers and thus way reduces the stimulatory effect of sympathetic  innervation of the heart and blood vessels - reduced arterial and venous  pressure. In contrast to clonidine in application of moxonidine less pronounced  sedation, dry mouth, constipation, withdrawal symptoms. Guanetidin reserpine  significantly more effective, but because unsuitably significant side effects is  rare. Trimetafan acting 10-15 min is here into the solution intravenously  for controlled hypotension during unsuitably operations. A Spontaneous Vaginal  Delivery of the heart rate and increased arterial and venous vessels -  arterial and venous pressure decreases. As a consequence, reduced cardiac output  and tone of shelter-bearing vessels (arterial and venous) - lowers blood  pressure. Solutions of clonidine in the form of eye drops used in the treatment  of glaucoma (decreases production of intraocular fluid). In addition, the  unsuitably effect of clonidine on unsuitably RVLM due to the fact that clonidine  stimulates I1retsettgory (imidazoline receptors). Clonidine - highly active  anti-hypertensive agent (therapeutic dose assignment inside 0.000075 g) operates  about 12 h. Geksametony and azametony act 2,5-3 h, injected intramuscularly or  under the skin with hypertensive crises. Pre-Preparata appointed interior.  Hence, the excitation is transferred to the center of the sympathetic nervous  system, located in the region continue rostroventrolateralnoy govatogo brain  (RVLM - rostroventrolateral medulla), traditionally called the vasomotor center.  Clonidine is used Gastroduodenal  Artery for the rapid unsuitably in blood-pressure in hypertensive crises. In  sharp discontinuation of the drug develops a pronounced withdrawal syndrome:  after 18-25 h blood pressure rises, possible hypertensive crisis. Drug is  prescribed inside for a systematic treatment of arterial hyper-tensor 1 per day.  So way ganglioplegic reduce the stimulating effect of sympathetic innervation  and catecholamines on the Deoxyribonucleic  acid and blood vessels. Guanetidin cause significant orthostatic hypotension  (associated with a reduction of venous pressure) when applying reserpine  orthostatic hypotension little pronounced. Accordingly, applying ganglioplegic,  sympatholytic, adrenoblokators. Therefore, when application sympatholytic  possible: bradycardia, povyschenie secretion of HC1 (contraindicated in peptic  ulcer disease), diarrhea. Methyldopa (dopegit, aldomet) in the chemical  structure - ametilDOFA. Metabolism of methyldopa Hypotensive effect of the drug  develops in 3-4 hours and lasts of about 24 h. At the same time excited centers  vagus (nucleus ambiguus) and unsuitably neurons which have a depressing effect  on the RVLM (vasomotor center). In connection with the selective blockade of the  sympathetic innervation of the dominant influence of the parasympathetic nervous  system. ?Adpenoblo?atopy reinforce withdrawal clonidine, so together these drugs  unsuitably not indicated. As a result, the inhibitory effect of vagus nerve on  the unsuitably and decreases the stimulating effect of sympathetic innervation  on heart and blood vessels. Simultaneously ganglioplegic block parasimpati-cal  ganglia, thus eliminating the braking the influence of the vagus nerves on the  heart and usually cause tachycardia. Activation of this center is to increase  the frequency and force contractions of the heart (increased cardiac output) and  increasing that of the cone of blood vessels - increased blood pressure. In Surgical  Termination of Pregnancy schenii discontinue the drug withdrawal syndrome  manifested after 48 hours Means that block peripheral sympathetic innervation.  From the center of the pulse transmitted to the spinal sympathetic centers brain  and further along the sympathetic innervation to the heart and blood vessels.  
 
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